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Myostatin Boy EssayMany scientists believe the find could eventu exclusivelyy lead to drugs for treating eople with fibrous dystrophy and early(a) muscle-destroying conditions. And athletes would almost surely want to get their hands on such a drug and use it worry steroids to bulk up. The boys fun DNA segment was found to block production of a protein called myostatin that limits muscle growth. The news comes seven years after researchers at Johns Hopkins University in Balti much created buff mighty mice by turning off the gene that directs cells to produce myostatin. Now we can say that myostatin acts the same way in humans as in animals, say the boys physician, Dr. Markus Schuelke, a professor in the child neurology department at Charite/ University Medical Center Berlin. We can apply that knowledge to humans, including trial therapies for muscular dystrophy. addicted the huge potential market for such drugs, researchers at universities and pharmaceutical companies already are trying to find a way to limit the amount and practise of myostatin in the bole. Wyeth has Just begun human tests of a catchingally engineered antibody designed to neutralize myostatin.Dr. Lou Kunkel, director of the genomics program at Boston Childrens Hospital and professor of pediatrics and genetic science at Harvard Medical School, said success is possible within several years. Just decreasing this protein by 20, 30, 50 percent can have a profound effect on muscle bulk, said Kunkel, who is among the doctors participating in the Wyeth research. Slow cachexia process Muscular dystrophy is the worlds most common genetic disease. There is no cure and the most common form, Duchennes, usually kills before adulthood.The few treatments being tried to slow its progression have serious view effects. Muscle asting also is common in the elderly and patients with diseases such as cancer and AIDS. If you could find a way to block myostatin activity, you might slow the wasting p rocess, said Dr. Se-Jin Lee, the Johns Hopkins professor whose team created the mighty mice. Lee said he believes a myostatin blocker also could suppress fat accumulation and thus nonplus the development of diabetes. Lee and Johns Hopkins would receive royalties for any myostatin-blocking drug made by Wyeth.Dr. Eric Hoffman, director of Childrens National Medical Centers Research Center for Genetic Medicine, said he believes a muscular dystrophy cure will be found, but he is unsure whether it will be a myostatin-blocking drug, another treatment or a combination, because about a dozen genes have some effect on muscles. He said a mystotatin- blocking drug could help other groups of people, including astronauts and others who lose muscle mass during long stints in zero gravity or when immobilized by illness or a broken limb. Eventual wellness problems?Researchers would not disclose the German boys identity but said he was born to a nd three other close male relatives all were unusual ly strong, with one of them a construction worker able to unload heavy curbstones by hand. In the mother, one copy of the gene is mutated and the other is conventionality the boy has two mutated copies. One almost definitely came from his father, but no information about him has been disclosed. The mutation is very rare in people. The boy is sizeable now, but doctors worry he could eventually suffer heart or other health problems.In the past few years, scientists have seen great potential in myostatin-blocking strategies. Internet marketers have been hawking myostatin-blocking supplements to bodybuilders, though doctors say the products are useless and perhaps dangerous. Some researchers are trying to turn off the myostatin gene in chickens to produce more meat per bird. And several breeds of cattle have natural variations in the gene that, aided by selective breeding, give them furthermost more muscle and less fat than other steer. He could do the iron cross when he was 5 months old, said his adoptive mother, Dana Hoekstra of Roosevelt Park.She was referring to a knotty gymnastics move in hich a male athlete suspends himself by his arms between two hanging rings, forming the shape of a cross. Liam has the kind of animal(prenominal) attributes that bodybuilders and other athletes dream about 40 percent more muscle mass than normal, Jaw-dropping strength, breathtaking quickness, a speedy metabolism and almost no body fat. Liam can run like the wind, has the agility of a cat, lifts pieces of furniture that most children his age couldnt push across a slick floor and eats like there is no tomorrow without gaining weight.Liam Hoekstra was hanging upside down by his feet when he performed an inverted sit-up, his shirt falling away to expose rippled ab muscles. It was a display of raw power one might expect to see from an Olympic gymnast. Liam is 19 months old. The so-called myostatin blockade has generated tremendous interest in the bodybuilding community. Som e nutritional supplements claim to block myostatin, but researchers have said the claims are not scientifically valid. If the myostatin protein is knocked out, muscles grow and rejuvenate much more uickly,